A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans
نویسندگان
چکیده
منابع مشابه
A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans.
Sex in fungi is driven by peptide pheromones sensed through seven-transmembrane pheromone receptors. In Cryptococcus neoformans, sexual reproduction occurs through an outcrossing/heterothallic a- sexual cycle or an inbreeding/homothallic - unisexual mating process. Pheromone receptors encoded by the mating-type locus (MAT) mediate reciprocal pheromone sensing during opposite-sex mating and cont...
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ABSTRACT Life-threatening infections caused by the encapsulated fungal pathogen Cryptococcus neoformans have been increasing steadily over the past 10 years. Cryptococcus neoformans is recognized as the most frequent fungal infection of the central nervous system (CNS) in immunocompetent as well as immunocompromised patients. We report the development of a semi-nested- PCR-based assay for the ...
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Seven nonencapsulated mutants of Cryptococcus neoformans were isolated from an encapsulated strain of human origin. Initially, the mutants were avirulent for mice. After several months of subculturing, six of the seven isolates reverted LO the encapsulated state and possessed varying degrees of virulence. The results of these experiments suggest that a strong correlation exists between the pres...
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Cryptococcus neoformans is a basidiomycetous, yeast-like fungus which, following inhalation from an environmental source, causes respiratory and neurological disease in humans and animals. Though the ecology of C. neoformans is poorly understood, recent observations provide clues about its life-cycle in nature. Two biotypes of C. neoformans are recognised, C. neoformans var. neoformans (serotyp...
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We examined the ploidy of C. neoformans strains using both laser scanning cytometry and a fluorescence microscope equipped with a photomultiplier. Haploid strains consisted of normal-sized cells with a haploid DNA amount. In the cell population there were also large-sized cells with a diploid DNA amount. These large cells in haploid strains were isolated using a Skerman micromanipulator, cultiv...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2009
ISSN: 0261-4189,1460-2075
DOI: 10.1038/emboj.2009.68